Weight Management Self-Scheduler

Qualified participants:

• Must be 18 years or older 

• Must have a BMI of 30 or over [calculate here]

• Must be comfortable speaking with our research team, attending regular clinic visits, and following study instructions for about 20 weeks

Answers Must Be No: 

• Have you ever been diagnosed with type 1 or type 2 diabetes? 

• In the past 6 months, have you been taking a GLP-1 medication for weight loss or diabetes such as Ozempic, Wegovy, Victoza, Trulicity, Mounjaro, or Zepbound? 

• In the past 6 months, have you gained or lost more than about 10–15 pounds, or are you currently enrolled in a structured weight loss program?

• Has a doctor ever told you that your weight is caused by a hormonal or genetic condition, such as Cushing’s syndrome or Prader-Willi syndrome?

• Do you have a history or current diagnosis of a pituitary gland disorder (a gland at the base of the brain that controls hormones)? 

• In the past 3 months, have you taken any of the following medications?
  • Tricyclic antidepressants: imipramine (Tofranil), amitriptyline (Elavil), mirtazapine (Remeron) 
  • Antipsychotics: chlorpromazine, thioridazine (Mellaril), clozapine (Clozaril), olanzapine (Zyprexa) 
  • Mood stabilizers: valproic acid / valproate / divalproex (Depakote), lithium 
  • Other antidepressants: paroxetine (Paxil), phenelzine (Nardil) 

• Do you have a history of — or are you currently being treated for — overactive thyroid (hyperthyroidism) with medications?

• Are you currently taking thyroid replacement medication at a dose greater than 75 mcg per day? 

• Have you ever been told you have anti-thyroid antibodies (a blood test result related to autoimmune thyroid disease)? 

• In the past 3 months, have you taken any medications that can affect thyroid function?

• Do you have a history of adrenal gland disease, such as Cushing’s syndrome or Addison’s disease? Or are you taking systemic (oral or IV) steroid medications?

• Have you had a heart attack, unstable chest pain (unstable angina), heart stent or bypass surgery, or stroke in the past 3 months? 

• Has a doctor told you that you have advanced heart failure?

• Are you currently taking a beta-blocker medication?

• Are you taking a statin (cholesterol-lowering) medication?

• Have you ever been diagnosed with advanced liver disease?

• Have you ever been diagnosed with medullary thyroid cancer?

• Have you ever taken a medication called Resmetirom (Rezdiffra)?

• Do you have a history of Pancreatitis, Crohn’s disease, Ulcerative colitis, Gastroparesis or stomach surgery?

• In the past year, have you regularly consumed more than the following amounts of alcohol for 3 or more consecutive months?
  • Men: More than 2 standard drinks per day (e.g., more than 2 beers, 2 glasses of wine, or 2 shots of liquor) 
  • Women: More than 1.5 standard drinks per day 

• In the past 5 years, have you had bariatric (weight loss) surgery — such as gastric bypass, gastric sleeve, or gastric band — or had a gastric balloon or intestinal bypass procedure?

• Have you been diagnosed with stage 3-5 CKD or receiving dialysis (hemodialysis or peritoneal dialysis)?

• .Do you have an active autoimmune condition that has required treatment with systemic (oral or IV) steroids or immune-suppressing medications in the past 3 months? This includes conditions such as lupus, rheumatoid arthritis, autoimmune hepatitis, or inflammatory bowel disease.

• Have you been diagnosed with cancer in the past — other than basal cell or squamous cell skin cancer, or cervical carcinoma in situ — that has not been in full remission for at least 5 years? Or do you have active, untreated cancer right now?

• Have you been diagnosed with major depressive disorder within the past 2 years, or do you currently have a diagnosis of a serious psychiatric condition such as schizophrenia, bipolar disorder, or dementia with psychosis?

• Have you ever had a suicide attempt, or in the past 30 days have you had thoughts of suicide that involved a specific plan or intent?

• In the past 5 years, have you used intravenous (IV) recreational drugs (drugs injected into a vein)? 

• Have you participated in another clinical trial or taken an investigational (experimental) medication within the past 30 days?

• Are you currently breastfeeding, or are you pregnant or planning to become pregnant during the next 6 months?

 Answers Must Be Yes 

• Are you willing and able to fast for 10 hours prior to every visit while in the study? (nothing to eat or drink except water)

• Are you willing and able to use effective birth control (or practice complete abstinence as your usual lifestyle) throughout the study and for 3 months after the last dose of study medication? 

• Have you had stable body weight within the last 6 months? 

• Are you able to pass a Urine Drug Screen?

PLEASE NOTE: Please confirm your eligibility before your appointment by calling 210-714-0067

• If you do not see an available appointment, please call 210-714-0067 for availability.

• Transportation may be available. Call 210-714-0067. Compensation up to $1,375 may be available for time and travel.

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