Obesity Study Self-Scheduler

Qualified participants must:

• Be 18 years and older

• Have a BMI 35 kg/m² or higher

• Have tried to lose weight with diet and exercise at least once in the past 6 months without lasting success

Answers Must Be No 

• Have you taken any of these medications within the past 3 months?
  • Semaglutide (Ozempic, Wegovy, Rybelsus)
  • Tirzepatide (Mounjaro, Zepbound)
  • Liraglutide 3 mg (Saxenda)
  • Any other GLP-1 receptor agonist medication (injectable medications for diabetes or weight loss)
  • Any other prescription weight loss medications like orlistat, phentermine, lorcaserin, naltrexone/bupropion combination, or phentermine/topiramate combination

• Have you ever had, or are you planning to have, any weight loss surgery or procedures such as:
  • Gastric bypass, Gastric sleeve, Lap band, Gastric balloon
  • Duodenal-jejunal liner, Gastric artery embolization
  • Any endoscopic weight loss procedure
  • (Note: Liposuction is okay if it was more than 1 year ago. If you had a device removed, it must have been more than 6 months ago.)

• Have you ever been diagnosed with diabetes (either Type 1 or Type 2) or have an A1c ≥6.5%?

• Are you currently taking any medications for blood sugar control, such as: Insulin (any type), Metformin (Glucophage), Sulfonylureas like glipizide (Glucotrol) or glyburide (Diabeta) or any other diabetes medications?

• Has your weight changed by more than 5% (up or down) in the past 3 months? (For example, if you weigh 200 pounds, that would be a 10-pound change.)

• Have you ever experienced diabetic ketoacidosis (a serious complication caused by insufficient insulin and high blood sugar) or a hyperosmolar coma (extremely high blood sugar with severe dehydration requiring immediate care)?

• Have you started taking any of these types of medications within the past 3 months?
  • Tricyclic antidepressants (like imipramine or amitriptyline)
  • Atypical antipsychotics (like clozapine, olanzapine, quetiapine)
  • Mood stabilizers (like valproic acid, lithium)
  • Mirtazapine (Remeron)
  • Paroxetine (Paxil)

• Have you taken, or are you likely to need, daily steroid pills or injections for more than 2 weeks within the past 3 months or in the next 12 months for significant active autoimmune conditions like lupus or rheumatoid arthritis? (Inhalers, nasal sprays, eye drops, skin creams, and joint injections are okay.)

• Are you allergic or have you had a bad reaction to any GLP-1 medications (like Ozempic, Wegovy, Trulicity, Victoza, Saxenda, Mounjaro, or Zepbound)?

• Within the past 2 years, have you had active or unstable (have you started any new meds or had any changes in dose) major depression, schizophrenia, bipolar disorder, or another serious mood or anxiety disorder?

• Have you been diagnosed with an eating disorder such as anorexia nervosa or bulimia nervosa? 

• Do you currently use marijuana (cannabis)? (If yes: Would you be willing to stop using marijuana for the duration of the study?)

• Within the past 3 months, have you had any of the following:
  • Heart attack, Stroke or mini-stroke (TIA), Unstable angina (chest pain)
  • Hospitalization for heart failure

• Do you have any of the following heart conditions:
  • Nonischemic cardiomyopathy (a type of heart muscle disease not caused by blocked arteries)
  • Class IV heart failure (the most severe type where you have symptoms even at rest)
  • Significant irregular heart rhythms

• Have you had cancer within the past 5 years? (Exceptions: Basal or squamous cell skin cancer, cervical carcinoma in situ, or prostate cancer in situ are okay.)

Answers Must Be Yes: 

• Are you willing to complete a self-injection training during the screening visit, including injecting your abdomen with saline under staff supervision?

• Are you willing to come to the clinic every 4 weeks for about a year and a half? 

• Are you willing and able to follow a reduced-calorie diet and mild-to-moderate exercise program throughout the study?

• If female of childbearing potential and sexually active, do you agree to use 2 highly effective forms of contraception?

• Male participants: Do you agree to refrain from donating sperm during the study and for at least 35 days after the end of the study? 

PLEASE NOTE: Please confirm your eligibility before your appointment by calling 210-714-0067

• If you do not see an available appointment, please call 210-714-0067for availability.

• Transportation may be available. Call 210-714-0067. 

• Compensation up to $2,430 may be available for time and travel.

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