Basic Criteria:
- Must be 18 years or older
- Must have very high triglycerides (at least 500 mg/dL)
- Must avoid new weight loss programs during study
- Must be available for all visits over 12 months
Answers Must Be No:
- Have you had a heart attack, stroke, stent, bypass surgery, or serious heart problem in the last 3 months?
- Do you have severe heart failure (NYHA Class III or IV)?
- Have you had pancreatitis in the last year?
- Must avoid new weight loss programs during study.
- Do you have familial chylomicronemia syndrome (FCS)?
- Do you have uncontrolled thyroid disease?
- Have you had cancer in the last 5 years (other than allowed skin or in‑situ cancers)?
- Do you have significant psychiatric conditions affecting participation?
- Have you had alcohol or drug abuse in the last 3 years?
- Do you have HIV, hepatitis B, or hepatitis C?
- Do you have severe drug allergies or prior severe hypersensitivity reactions?
- Are you pregnant, breastfeeding, or planning pregnancy (if applicable)?
- Have you received gene therapy, gene editing therapy, or small interfering RNA treatments in the last 12 months?
- Have you used an investigational medication in the last 30 days?
- Have you had large recent weight changes (>5 kg in 3 months)?
- Do you have uncontrolled high blood pressure (≥180/100)?
- Have you donated blood recently (≥50 mL in last 4–8 weeks)?
- Are you unwilling to limit alcohol to moderate levels?
Answers Must Be Yes
- Are you 18 years or older?
- Have you been told you have very high triglycerides (at least 500 mg/dL)?
- Do you have two fasting triglyceride readings ≥500 mg/dL taken at least 7 days apart?
- Is your BMI between 18.5 and 45?
- Are you willing to follow study instructions (fasting before visits, stable diet, visits every 4–6 weeks)?
- If you take lipid‑lowering medications (like statins, fibrates, omega‑3s), have you been on a stable dose for the required time?
- Are you willing to avoid new weight‑loss programs during the study?
- Are you available for all visits over about 12 months?
- Is your BMI between 18.5 and 45?
- Are you willing to follow study instructions (fasting before visits, stable diet, visits every 4–6 weeks)?
- Are you able to give informed consent?
PLEASE NOTE: Please confirm your eligibility before your appointment by calling 312-931-8883
- If you do not see an available appointment, please call 312-931-8883 for availability.
- Compensation up to $1,933 may be available for time and travel.
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