High Cholesterol and Heart Disease Study Self-Scheduler

Basic Criteria: 

• Be 18-70 years of age 

• Have heterozygous familial hypercholesterolemia (HeFH) or a history of early heart disease

• rLDL (“bad”) cholesterol of 70 mg/dL or higher

Please note additional criteria will apply 

Answers Must Be No: 

• Do you have unstable or severe heart disease or a recent heart attack?

• Do you have homozygous familial hypercholesterolemia?

• Do you have poorly controlled diabetes (HbA1c >9%)?

• Do you have active or chronic liver disease (other than Gilbert syndrome)?

• Do you have uncontrolled high blood pressure?

• Do you have very high triglycerides (≥500 mg/dL)?

• Do you have significant kidney disease?

• Are you currently taking blood thinners or have a history of blood clots?

• Do you have a history of cancer (except certain skin cancers)?

• Are you currently using or recently used a PCSK9 inhibitor?

• Are you pregnant or breastfeeding?

• Do you have a serious psychiatric or neurological condition that would interfere with participation?

Answers Must Be Yes 

• Are you 18–70 years old?

• Do you have heterozygous familial hypercholesterolemia (HeFH) or a history of early heart disease (heart attack, stent, bypass, or artery blockage before age 55 for men or 65 for women)?

• Is your LDL (“bad”) cholesterol 70 mg/dL or higher?

• Are you taking the highest dose of statin and/or ezetimibe you can tolerate, with no recent changes?

• Has your cholesterol treatment been stable for at least 30 days?

• Have you discussed other approved cholesterol treatments with your doctor and decided to consider this study?

• Is your BMI between 18 and 40?

• Are you willing to not donate blood during the study?

• Are you willing to take part in long‑term follow‑up for up to 15 years?

• If male: are you willing to use contraception and not donate sperm for 90 days after dosing?

• If female: are you postmenopausal or permanently unable to become pregnant?

• Are you able and willing to provide informed consent and follow study requirements?

  Additional criteria will apply

• PLEASE NOTE: Please confirm your eligibility before your appointment by calling 561-513-6266
  • If you do not see an available appointment, please call 561-513-6266 for availability.
  • Transportation may be available. Call 561-513-6266. Compensation may be available for time and travel.