Diabetes Medication Study Self-Scheduler

 Basic Criteria 

• Must be 18-75 years old.

• BMI must be between 23– 50 kg/m² [calculate here].

• Must have been diagnosed with Type 2 diabetes at least 6 months ago.

• A1C must be between 7.0% and 10.5%. 

• Must be on a stable dose of at least 1000 mg of metformin with or without an SGLT2 inhibitor (such as Jardiance, Farxiga, Invokana, Steglatro, or generic versions) for at least 3 months.

• Weight should not have changed by more than 5% in the last 3 months 

Answers Must be NO 

• Have you ever had Type 1 diabetes or diabetic ketoacidosis (DKA)?

• Have you taken a GLP‑1 medication in the past 6 months (e.g., Ozempic, Mounjaro, Trulicity, Victoza, Byetta/Bydureon, Rybelsus, Saxenda, Wegovy)?

• In the past 3 months, have you taken any diabetes medications besides metformin, SGLT2 inhibitors or weight loss medications?

• Have you used insulin for diabetes in the past 12 months? (Short-term use less than 14 days for hospital/surgery/pregnancy is allowed.)

• Have you had more than one severe low blood sugar episode in the past 6 months?

• Are you pregnant, breastfeeding, or planning pregnancy during the study?

• In the past 6 months, have you had a heart attack, stroke, TIA, heart surgery, angioplasty/stenting, or unstable angina?

• Do you have severe heart failure (NYHA Class III or IV) or any heart rhythm issues?

• Do you have stage 3–5 chronic kidney disease?

• Have you ever had pancreatitis, symptomatic gallbladder disease or thyroid disease?

• Have you had any cancer within the past 5 years? (Except basal cell skin cancer, low‑risk prostate cancer, or cervical carcinoma in situ.)

• Do you have gastroparesis, Crohn’s disease, ulcerative colitis, inflammatory bowel disease, or prior GI surgery (other than appendectomy or polyp removal)?

• Are you taking long‑term GI motility medications such as mosapride or cisapride?

• Do you have known or active liver disease (hepatitis B, hepatitis C, or cirrhosis)?

• Are you currently taking any of these medications: strong CYP3A4 inhibitors/inducers, or CYP2D6 inhibitors/inducers?

• Do you have uncontrolled diabetic retinopathy or maculopathy?

• Do you plan to start or change medications during the study that could affect weight or blood sugar (e.g., orlistat, thyroid hormones, oral steroids longer than 14 days)?

• In the past 60 days, have you taken an investigational drug, or in the past 30 days used an investigational device?

Answers Must be YES 

• If you are a woman who could become pregnant: Are you willing to use two approved methods of birth control throughout the study and for 30 days after? 

• For women of nonchildbearing potential: Are you either postmenopausal or permanently sterilized?

• If you are a man who could father a child: Are you willing to use a condom if your partner could become pregnant, throughout the study and for 90 days after? 

• Are you willing to maintain your current physical activity level during the study and avoid starting a structured weight loss diet or exercise program? 

• Are you willing not to donate blood or blood products during the study and for 8 weeks following the study? 

• Are you willing to come to the clinic for regular visits over the 6-month study period? 

• Are you willing to monitor your blood sugar at home and report any symptoms? 

PLEASE NOTE: Please confirm your eligibility before your appointment by calling 210-714-0067

• If you do not see an available appointment, please call 210-714-0067 for availability.

• Transportation may be available. Call 210-714-0067. 

• Compensation up to $2,520 may be available for time and travel.

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