Weight Management Medication Research Study

Qualified participants:

• Must be 18-75 years old

• For patients with Type 2 Diabetes: BMI must be 27 or higher [calculate here]

• For patients without Type 2 Diabetes: BMI must be 30 or higher OR 27 or higher with at least one of: high blood pressure, high cholesterol/triglycerides, diagnosed sleep apnea, cardiovascular disease [calculate here]

• Must have tried to lose weight through diet and exercise in the last 6 months without success 

• Must be able to provide medical records 

Answers Must Be NO: 

• For non-diabetics- Are you currently taking insulin, a sulfonylurea such as glipizide, glimepiride, or glyburide, or metformin for blood sugar control? 

• For Type 2 diabetics – Are you taking anything other than metformin or an SGLT2 inhibitor such as Jardiance, Farxiga, or Invokana?

• • Do you have a history of diabetic ketoacidosis or hyperosmolar state/coma, hypoglycemia or hypoglycemia unawareness in the past 1 year? 
  • Do you have a history of proliferative diabetic retinopathy, diabetic maculopathy, or nonproliferative diabetic retinopathy that required acute treatment? 

• In the last 3 months, have you used any of the following weight-loss or diabetes medications: Ozempic, Wegovy, Victoza, semaglutide, Mounjaro, Zepbound, tirzepatide, Saxenda, liraglutide 3 mg, or any other GLP-1 medication or injectable weight-loss drug?

• In the last 3 months, have you used any prescription or over-the-counter weight-loss medications or treatments such as: Qsymia, Contrave, Xenical, Alli, orlistat, phentermine, or weight-loss teas or supplements? 

• Have you ever had weight-loss surgery or a weight-management procedure or are you planning to have any of these procedures in the next year? 

• Has your body weight changed by more than 5% in the last 3 months? For example, if you weigh 200 lbs, that would be a gain or loss of more than 10 lbs. 

• Have you received an organ transplant, or are you currently waiting for an organ transplant such as: Kidney, liver, or heart transplant?

• Have you participated in a clinical research study and received a study medication within the last 30 days? 

• In the last 3 months, have you been hospitalized for a heart attack, stroke, unstable chest pain, or heart failure? 

• Have you been diagnosed with a type of heart failure called NYHA Class IV — meaning you have symptoms even at rest, or a serious heart rhythm disorder? 

• Have you been diagnosed with active hepatitis B, hepatitis C, or HIV? 

• Have you ever been diagnosed with pancreatitis, which is inflammation of the pancreas?

• Have you or any blood relative ever been diagnosed with medullary thyroid carcinoma, a specific type of thyroid cancer, or a condition called Multiple Endocrine Neoplasia Type 2? 

• Have you been diagnosed with any type of cancer in the last 5 years?

• In the last 3 months, have you started taking any of the following types of medications: Tricyclic antidepressants, Antipsychotics, mood stabilizers?

• In the last 3 months, have you been taking oral or injected steroid medications or in the next 12 months, do you expect to need long-term steroid treatment — more than 2 weeks — for an autoimmune condition such as: Prednisone, methylprednisolone, or dexamethasone for an ongoing autoimmune condition like lupus or rheumatoid arthritis.

• Are you currently taking any medications prescribed specifically to help move food through your digestive system, such as metoclopramide or Reglan?

• In the last 2 years, have you been diagnosed with or treated for a serious psychiatric condition or in the last year, have you been hospitalized or had an urgent visit to the emergency room due to a psychiatric condition.

• Have you ever attempted suicide? 

• Do you have a known problem with drug or alcohol use or, in the last 3 months, have you used marijuana including edibles, oils, or CBD products?

• Have you ever been diagnosed with an eating disorder such as anorexia, bulimia, or binge eating disorder? 

• Have you been diagnosed with severe gastroparesis, which is very slow stomach emptying, gastric outlet obstruction, Crohn’s disease, ulcerative colitis, or irritable bowel syndrome that significantly affects your daily life? 

• Do you have any serious liver, kidney, or digestive conditions beyond what we have already discussed that your doctor has told you could affect how your body processes medications?

• Are you currently pregnant, planning to become pregnant in the next year, or currently breastfeeding? 

• Have you ever had an allergic reaction or serious side effects from a GLP-1 medication such as Ozempic, Victoza, or Trulicity? 

Answers Must Be YES: 

• This study involves clinic visits over about 11 months, taking a daily pill, following a lifestyle program, and completing questionnaires. Are you willing and able to commit to all these requirements? 

• Contraception use:
  • Women of non-childbearing potential must have one of the following;
    • Permanent sterilization such as hysterectomy or bilateral oophorectomy 
    • Medically documented ovarian failure 
    • Postmenopausal
  • Women of childbearing potential must have one of the following;
    • Agree to refrain from donating ova or attempting to get pregnant during the study until at least 3 days after the end of treatment
    • If sexually active and engaging in heterosexual intercourse, MUST agree to use 2 methods of effective contraception
  • Male participants must:  
    • Agree to refrain from donating sperm during the study until at least 3 days after the end of treatment. 
    • If sexually active with a partner of childbearing potential, must use a condom in addition to a highly effective contraception 

PLEASE NOTE: Please confirm your eligibility before your appointment by calling 210-714-0067

• If you do not see an available appointment, please call 210-714-0067 for availability.

• Transportation may be available. Call 210-714-0067. Compensation up to $1,975 may be available for time and travel.

By signing up, you agree to receive text messages and emails about this and similar studies near you. You can unsubscribe at any time. Text messages and data rates may apply.